Our Iron Will: Trasfusional iron overload

The risk of life-threatening complications increases as iron builds-up in the organs

Create infographic with copy below

60-70% of deaths in people, with thalassaemia major are due to heart complications and disease.6 *

Create infographic with copy below

People with sickle cell disease receiving transfusions had 4.1 hospital stays per year vs. 2.1 for non-transfused patients.7 †

The death rate is 3X higher among people with thalassaemia major and sickle cell disease with transfusional iron overload.7 †

* Based on a total of 1,073 patients diagnosed with thalassaemia major before the age of 3.
† Based on a study of patients who were either currently on or had received regular transfusion therapy and confirmed to have iron overload as defined by a liver iron concentration (LIC) of >10 mg/g dry weight or 3 serum ferritin values that averaged ≥2,000 ng/mL within the previous 12 months. 142 patients with thalassaemia and 199 patients with sickle cell disease who received regular transfusions were included in the study group and compared with 64 non-treated sickle cell disease patients as controls. Despite improvements in therapy, death rate in this contemporary sample of transfused adult subjects with Thal or SCD is 3 times greater than the general US population

The goal of iron chelation therapy is to be efficient whilst minimising side effects3,6,7

Appropriate chelation needs to be regularly adjusted based on iron level, patient’s weight, and side effects experienced.1, 4, 8 Talk to your doctor about how you feel and be sure to tell him about side effects like hearing loss, vision problems, kidney issues or gastrointestinal side effects (e.g. nausea and vomiting) that keep you from taking your medication as prescribed.

Appropriate iron chelation, at the appropriate dose, removes extra iron from the body and organs to help prevent damage caused by iron overload4,8

Goals of appropriate chelation therapy

VISUAL – FPO – to be recreated VISUAL – FPO – to be recreated VISUAL – FPO – to be recreated

Patients & Caregivers: in case of need to report an adverse drug reaction, please refer to your physician, asking him to fill in and submit the relevant case report to the concerned Health Authority, according to the Pharmacovigilance requirements in force in your Country. Nevertheless, please be kindly reminded that each patient can report any such cases directly to the national reporting system.